Depriving your body of sleep could take the same kind of toll on your immune system as being stressed, a new study suggests.

Researchers from the Netherlands and the United Kingdom found that white blood cell counts (also known as granulocytes) jumped at night when the men in the study were severely sleep-deprived, and they also had a decrease in rhythmicity between the daytime and the nighttime.

“The granulocytes reacted immediately to the physical stress of sleep loss and directly mirrored the body’s stress response,” study researcher Katrin Ackermann, Ph.D., a postdoctoral researcher at the Eramus MC University Medical Center Rotterdam, said in a statement.

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